Notes: Benoxaprofen is a non-steroidal anti-inflammatory drug.{64474} It inhibits prostaglandin E2 (PGE2; Item No. 14010) and leukotriene C4 (LTC4; Item No. 20210) production in isolated mouse peritoneal macrophages stimulated with A23187 (Item No. 11016 / 22030) when used at a concentration of 100 µM.{57231} Benoxaprofen (25 and 50 µg/ml) inhibits serum-induced chemotaxis of isolated rat peritoneal leukocytes.{64475} It induces hemolysis in isolated human erythrocytes and histamine release in isolated rat peritoneal mast cells in a light-dependent manner when used at a concentration of 10 µM.{64476} Benoxaprofen reduces carrageenan-induced paw edema and yeast-induced fever in rats and acetic acid-induced writhing in mice in a dose-dependent manner.{64474} Formulations containing benoxaprofen have previously been used in the treatment of osteoarthritis and rheumatoid arthritis.