Formulation: A solid
Formal Name: 3,4,4aS,5,16aR,17,18,19-octahydro-21,22,26-trimethoxy-4,17-dimethyl-16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido[2′,3′:17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolin-12-ol, dihydrochloride
Purity: ≥95%
Formula Markup: C37H40N2O6 • 2HCl
Formula Weight: 681,7
Shelf life (days): 1460
CAS Number: 6078-17-7
Notes: Berbamine is a bisbenzylisoquinoline alkaloid that has been found in B. aristata and has diverse biological activities.{69057,69058,69059,69060} It induces apoptosis and autophagy in, and is cytotoxic to, HT-29 cells when used at concentrations ranging from 3 to 100 µM.{69057} Berbamine reduces viral infectivity in Vero E6 cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; IC50 = 2.35 µM) and decreases cell surface levels of angiotensin-converting enzyme 2 (ACE2) in Huh7 cells when used at a concentration of 10 µM.{69058} In vivo, berbamine (25 and 50 mg/kg) reduces hepatic lipid accumulation and inflammatory cytokine levels, serum and hepatic triglyceride and total cholesterol levels, and serum aspartate aminotransferase (AST) and alanine transaminase (ALT) levels in a mouse model of ethanol-induced liver injury.{69059} It also protects against myocardial apoptosis, mitochondrial dysfunction, and lipid peroxidation in a rat model of myocardial infarction induced by isoproterenol (Item No. 15592).{69060}
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