Formulation: A solid
Formal Name: 4-hydroxy-7H-furo[3,2-g][1]benzopyran-7-one
Purity: ≥95%
Formula Markup: C11H6O4
Formula Weight: 202,2
Shelf life (days): 730
CAS Number: 486-60-2
Notes: Bergaptol is a furanocoumarin that has been found in A. dahurica and has diverse biological activities.{47083,64926,60976,64927} It inhibits the cytochrome P450 (CYP) isoform CYP3A4 (IC50 = 24.92 µM).{64926} It scavenges DPPH (Item No. 14805) and ABTS (Item No. 27317) radicals in cell-free assays (EC50s = 26.66 and 13.55 µg/ml, respectively).{47083} Bergaptol reduces the replication of L. donovani, T. b. brucei, and T. cruzi in L6 myoblasts (IC50s = 2.5, 22.1, and 68 µg/ml, respectively).{60976} It induces cell cycle arrest at the S phase and apoptosis in MCF-7 breast cancer cells in a concentration-dependent manner.{64927} Bergaptol also decreases the proliferation of HeLa cervical carcinoma and HepG2 liver cancer cells (IC50s = 58.57 and 68.42 µM, respectively).{47083}
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