Product Description: Goat polyclonal antibody to beta 2 Defensin
Specificity/Sensitivity: This antibody recognizes human Defensin beta-2 (BD-2), a ~4./3kDa cationic antimicrobial peptide, also known as Beta-defensin 4A or Skin-antimicrobial peptide 1 (SAP-1) expressed primarily by epithelial cells of the respiratory tract and skin, and an important component of the innate immune response against microbial infections./Expression of BD-2 is induced during inflammation in response to bacterial products and cytokines, and is initially expressed in a precursor form, which is cleaved to release the C-Terminal active portion of the protein which is secreted by the neutrophil and binds to bacterial membranes causing their disruption.
Form: Lyophilized powder
Buffer (with preservative): Phosphate buffered saline
Concentration: 0.1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Jul 2008]
Antigen Species: Pig
Immunogen: Recombinant human Defensin beta-2.
Purification: Antisera to human Defensin beta 2 were raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Conjugation: Unconjugated
Full Name: defensin, beta 4A
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