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CAS Number: 755038-02-9
Description: BI-2536 is a potent, ATP-competitive, well tolerated and effects Polo-like kinases (Plks) as well as a pan-BET (bromodomain and extra-terminal motif) family inhibitor. BI-2536 has an IC50 of 0.83 and 25 nM with PLK1 and BRD4 inhibitor, respectively. BI-2536 also blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. BI-2536 suppresses IFNB (encoding IFN-ß) gene transcription. It also shows good blood-brain barrier permeability and causes mitotic arrest in glioblastoma-derived neural stem cells but not normal neural stem cells.
Format: Solid
Purity: 0,95
Storage Stability: At least 6 months at -20°C.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
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