Formulation: A mixture in methanol (see CofA for concentrations)
Shelf life (days): 1095
Notes: Bile Acids MaxSpec® Discovery Mixture contains a variety of standards for the analysis of bile acids. Bile acids are formed in the liver primarily from cholesterol and then transformed by intestinal microbiota into a diverse array of secondary bile acids.{54792,48224} Primary and secondary bile acids can be modified by conjugation to glycine or taurine via an amide linkage. Bile acids are involved in the degradation of cholesterol in the liver and the solubilization of fatty acids in the small intestine and lipophilic xenobiotics in the biliary tract.{54792} They also bind to and activate bile acid receptors, such as the farnesoid X receptor (FXR) and G protein-coupled bile acid-activated receptor (GP-BAR), which are involved in lipid, glucose, and energy metabolism.{37056} The Bile Acids MaxSpec® Discovery Mixture contains primary and secondary bile acids, as well as glycine- and taurine-conjugated bile acids. Bile Acids MaxSpec® Discovery Mixture has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. The verified concentration is provided on the certificate of analysis. This Bile Acids MaxSpec® Discovery Mixture is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.
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