Formulation: A solid
Formal Name: (5α,7E)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-7-(phenylmethylene)-morphinan-6-one, 2Z-butenedioate
Purity: ≥95%
Formula Markup: C27H27NO4 • C4H4O4
Formula Weight: 545,6
Shelf life (days): 1460
CAS Number: 864461-31-4
Notes: BNTX is a δ1-opioid receptor antagonist (Ki = 0.1 nM).{49810} It is selective for the δ1-opioid receptor over the δ2-, μ-, and κ-opioid receptors (Kis = 10.8, 13.3, and 58.6 nM, respectively). BNTX (1 and 10 µM) decreases proliferation of primary mouse splenic B cells and the production of IL-2 and IL-4 by primary mouse splenic T lymphocytes.{49811} It has antinociceptive activity in the tail-flick test in mice (ED50 = 46.4 pmol/animal) and decreases the antinociceptive activity of the δ1-opioid receptor agonist DPDPE (Item No. 23184) when administered at a dose of 6.3 pmol/animal.{49810} BNTX (0.3-3 mg/kg) decreases the number of coughs induced by the terpene alkaloid capsaicin (Item No. 92350) in mice.{49812} It also reduces the number of parasitized red blood cells in a mouse model of chloroquine-resistant P. chabaudi infection when administered at a dose of 10 mg/kg.{49813}
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