BRD0639

Formulation: A solid

Formal Name: (S)-2-(4-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-(N-(2-(pyridin-2-yl)ethyl)sulfamoyl)phenyl)propanamide

Purity: ≥98%

Formula Markup: C21H22ClN5O4S

Formula Weight: 475,9

Shelf life (days): 1460

Notes: BRD0639 is an inhibitor of the protein-peptide interaction between protein arginine methyltransferase 5 (PRMT5) and PRMT5 binding motif (PBM; IC50 = 13.8 µM), a conserved peptide motif contained in PRMT5 substrate adaptor proteins (SAPs) that mediates SAP binding to PRMT5.{62562} It induces the formation of PRMT5 adducts in cells (EC50 = 3 µM) and disrupts complex formation between PRMT5 and the SAP RIO kinase 1 (RIOK1) in permeabilized cells.

• SKU: CAY35625-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 35625-25
• Green Labware: No
• Package Unit: 25 mg
• Quantity Unit: STK
• Application: Reinstoffe