BRD7116, CAS 329059-55-4

Formulation: A crystalline solid

Formal Name: N,N'-(sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl-cyclopropanecarboxamide

Purity: ≥98%

Formula Markup: C28H36N2O4S

Formula Weight: 496,7

Shelf life (days): 1460

CAS Number: 329059-55-4

Notes: BRD7116 is a bis-aryl sulfone that acts as a selective inhibitor of leukemia stem cell activity. It exhibits an EC50 value of 200 nM for leukemia stem cells isolated from the bone marrow of leukemic animals in co-culture but does not affect normal hematopoietic stem cells or AML cell lines (EC50s = 20 µM).{32403} Its exact mechanism is not well understood but is thought to involve impairment of the stroma’s ability to support leukemia stem cells by inducing transcriptional changes consistent with myeloid differentiation.{32403}

• SKU: CAY20570-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 20570-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK
• Application: Reinstoffe