Product Type: Inhibitor
CAS No.: 20350-15-6
MolecularFormula: C16H24O4
Molecular Weight: 280,36
Source: Synthetic
Purity: >98%
Solubility: Soluble to 10 mM in ethanol and to 50 mM in DMSO
Appearance: White Crystalline Solid
PubChem CID: 5287620
Scientific Background: Brefeldin A is a reversible inhibitor of proteins from the endoplasmic reticulum (ER) to the golgi. In mammalian and yeast cells, Brefeldin A targets certain GTP-exchange factosr responsible for activating a GTPase called Arf1p (1, 2).
References: 1. Klausner R.D., Donaldson J.G., Lippincott-Schwartz J. (1992) J Cell Biol. 116(5): 1071-1080.2. Nebenfuhr A., Ritzenthaler C., and Robinson D.G. (2002) Plant Physiol. 130(3): 1102-1108.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.