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Clone Name: MSVA-397R
Light Chain: Kappa
Product Description: This antibody was validated on 76 different Normal and cancerTissues by IHC-P.
Application Note: IHC-P: 1:100-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 185
Positive Control: Kidney: All cells should display an at least moderate nuclear SMARCA4 immunostaining.
Negative Control: A tumor (or cell line) with documented SMARCA4 expression loss should be used as a “negative” control (as SMARCA4 is expressed in all normal tissues)
Form: Liquid
Buffer (with preservative): 10mM PBS, 0.05% BSA (Please contact us for sodium azide-free or sodium azide and BSA-free format), 0.05% sodium azide.
Concentration: 0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Background: The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Uniprot ID: P51532
Antigen Species: Human
Immunogen: Recombinant fragment (around aa 190-400) of human SMARCA4 protein
Purification: Protein A/G purified
Conjugation: Unconjugated
Full Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
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