Formulation: A solid
Formal Name: P-[[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-phosphonic acid, mono[3-(hexadecyloxy)propyl] ester
Purity: ≥98%
Formula Markup: C27H52N3O7P
Formula Weight: 561,7
Shelf life (days): 1460
CAS Number: 444805-28-1
Notes: Brincidofovir is a prodrug form of the antiviral and acyclic nucleoside phosphonate cidofovir (Item No. 13113).{61832} Brincidofovir is converted to cidofovir in MRC-5 human lung fibroblasts. It inhibits CMV, herpes simplex virus 1 (HSV-1), HSV-2, cowpox, and vaccinia virus replication in plaque reduction assays (EC50s = 0.0009, 0.06, 0.08, 0.6, and ~1 µM, respectively). Brincidofovir decreases mortality in mouse models of cowpox or vaccinia virus infections when administered at doses of 6.7 or 5 mg/kg, respectively.{61833} Formulations containing brincidofovir have been used in the treatment of smallpox disease.
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