Target: BRSK1 (pThr189).
Conjugate: ATTO 594.
Product Type: Polyclonal.
Immunogen: A phospho-specific peptide corresponding to residues surrounding Thr189 of human BRSK1 (AA186-192).
Swiss-Prot: Q8TDC3.
Purification: Peptide Affinity Purified.
Storage Buffer: PBS pH7.4, 50% glycerol, 0.025% Thimerosal.
Specificity: Detects 86.753 kDa.
Cellular Localization: Cytoplasm, Nucleus.
Scientific Background: BRSK1 (BR serine/threonine-protein kinase 1), also known as SAD1, is a 794 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one UBA domain and one protein kinase domain. Expressed in a variety of tissues with highest expression in testis and brain, BRSK1 uses magensium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins, including Wee 1 and Cdc25B. Via its kinase activity toward proteins that are involved in microtubule assembly, BRSK1 plays an essential role in neuronal polarization and may be involved in regulating cell cycle arrest in response to DNA damage, Two isoforms of BRSK1 exist due to alternative splicing events.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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