Product Type: Inhibitor
CAS No.: 328968-36-1
MolecularFormula: C24H19N3O6
Molecular Weight: 445,4
Source: Synthetic
Purity: >98% (TLC), NMR conforms
Solubility: Soluble in 10 mg/ml DMSO
Appearance: Orange Solid
PubChem CID: 1285940
Scientific Background: Potent and selective inhibitor of the histone acetyl transferase p300/CBP (Ki=400 nM ). Induces apoptosis in prostate cancer cells. Enhances fear extinction memory and synaptic plasticity in mice. Promotes tau deacetylation reducing levels of pathogenic p-tau. Cell permeable.
References: 1. Bowers E.M., et al. (2010) Chem. Biol. 17: 471.2. Santer F.R., et al. (2011) Mol. Cancer Ther. 10: 1644.3. Marek R., et al. (2011) J. Neurosci. 31: 7486.4. Min S.W., et al. (2010) Neuron 67: 953.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.