Product Type: Activator
CAS No.: 178946-89-9
MolecularFormula: C23H17ClN2
Molecular Weight: 356,9
Source: Synthetic
Purity: >98% (TLC); NMR (Conforms)
Solubility: May be dissolved in DMSO (35 mg/ml); or ethanol (35 mg/ml)
Appearance: Orange powder
PubChem CID: 5302583
Scientific Background: C-DIM 12 is a nurr1 activator that inhibits bladder cancer growth (1,2). It also inhibits NF-κB and cytokine expression in microglial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters (3). It displays neuroprotective activity in a mouse Parkinson's disease models (4).
References: 1.Inamoto T., et al. (2008) Mol. Cancer Ther. 7:38252.Li X., et al. (2012) Biochem. Pharmacol. 83:14453.De Miranda B.R.,et al. (2015) Mol. Pharmacol. 87:10214.De Miranda B.R., et al. (2013) J. Pharmacol. Exp. Ther. 345:125
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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