C14-4, CAS 2639634-80-1

Formulation: A solution in ethanol

Formal Name: 1,1′-[[2-[2-[4-[2-[[2-[2-[bis(2-hydroxytetradecyl)amino]ethoxy]ethyl](2-hydroxytetradecyl)amino]ethyl]-1-piperazinyl]ethoxy]ethyl]imino]bis-2-tetradecanol

Purity: ≥95% (mixture of isomers)

Formula Markup: C84H173N5O7

Formula Weight: 1365,3

Shelf life (days): 365

CAS Number: 2639634-80-1

Notes: C14-4 is an ionizable cationic lipid (pKa = 6.5).{68390,68391} It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA. LNPs containing C14-4 and encapsulating mRNA encoding chimeric antigen receptor (CAR) induce CAR expression in primary human T cells ex vivo to the same level as expression induced via electroporation, but with reduced cytotoxicity, and induce cytotoxicity in Nalm-6 acute lymphoblastic leukemia (ALL) cells in vitro.{68390}

• SKU: CAY38942-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 38942-1
• Package Unit: 1 mg
• Quantity Unit: STK
• Application: Reinstoffe