Clone Name: hHCD
Application Note: IHC-P: 1:50-1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 93
Positive Control: Endometrial cancer
Specificity/Sensitivity: This antibody is specific to high molecular weight (120-150 kDa) h-caldesmon. The h-caldesmon variant is predominantly expressed in smooth muscle, whereas l-caldesmon (71-80 kD) is found in non-muscle tissue and cells.
Form: Liquid
Buffer (with preservative): PBS, 0.1% BSA, 0.05% Sodium azide.
Concentration: Batch dependent (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Uniprot ID: Q05682
Antigen Species: Human
Immunogen: BALB/C mice were injected with human uterus smooth muscle extract.
Purification: Purified IgG
Conjugation: Unconjugated
Full Name: caldesmon 1
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