Product Type: Inhibitor
CAS No.: 7689-03-4
MolecularFormula: C20H16N2O4
Molecular Weight: 348,36
Source: Synthetic
Purity: >98%
Solubility: Soluble to 5 mM in DMSO
Appearance: Yellow solid
PubChem CID: 24360
Scientific Background: Camptothecin is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I. It binds to the topo I and DNA complex, resulting in a tertiary comlex which stabilizes it. This prevents re-ligation and therefore causes DNA damage which results in apoptosis (1-3). It has showed remarkable anti-cancer activity in clinical trials.
References: 1. Adams D.J., et al. (2005) Cancer Chem and Pharm. 57(2): 145-154.2. Redinbo M.R., Stewart L., Kuhn P., Champoux J.J. and Hol W.G.J. (1998) Science. 279:1504-1513.3. Pommier Y., et al. (2003) Mutat Res. 532: 173-203.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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