Product Type: Small Molecules
CAS No.: 404-86-4
MolecularFormula: C18H27NO3
Molecular Weight: 305,41
Source: Synthetic
Purity: >60% (HPLC); NMR (conforms)
Solubility: Soluble in DMSO (20 mg/mL) and ethanol (15 mg/mL)
Appearance: Off-White Solid
PubChem CID: 1548943
Scientific Background: Capsaicin is an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel (1, 2). It exhibits neuroprotective effects in a model of transient global cerebral ischemia and induces release of substance P from afferent nociceptive specific neurons (1). Powerful excitant of peripheral sensory nerve endings, specifically unmyelinated afferent neurons (C-fibers). Reversibly inhibits aggregation of platelets (3).
References: 1. Caterina M.J., et al. (1997) Nature. 389(6653): 816-824.2. Story G.M., Crus-Orengo L. (2007) Am Scientist. 95(4): 326-333.3. Vaishnava P., Wang D.H. (2003) Curr Med Chem Cadiovasc Hematol Agents. 1(2): 177-188.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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