Formulation: A solid
Formal Name: (αS)-α-hydrazinyl-3,4-dihydroxy-α-methyl-benzenepropanoic-2,5,6-d3 acid, monohydrate
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C10H11D3N2O4 • H2O
Formula Weight: 247,3
Shelf life (days): 1460
CAS Number: 1276197-58-0
Notes: Carbidopa-d3 is intended for use as an internal standard for the quantification of carbidopa (Item No. 23783) by GC- or LC-MS. Carbidopa is a peripherally restricted inhibitor of dopamine decarboxylase, the enzyme that converts L-DOPA (Item No. 13248) to dopamine.{41269} Administration of carbidopa (100 mg/kg) prior to administration of L-DOPA in dogs increases the plasma concentration of L-DOPA by 186% and prolongs the half-life in plasma by 48% and skeletal muscle extracellular fluid by 66%.{41270} Carbidopa also binds to and potentiates the activity of the aryl hydrocarbon receptor (AhR).{41271} It inhibits the proliferation of pancreatic cancer cells in vitro and tumor growth in vivo. Formulations containing carbidopa are used in combination with L-DOPA in the treatment of Parkinson’s disease to increase the amount of dopamine in the brain and reduce peripheral side effects associated with L-DOPA administration.
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