Clone: CA2.
Conjugate: APC.
Carboxypeptidase A is a protease that hydrolyses the C-terminal peptide bond in polypeptide chains. Whilst this enzyme demonstrates strict specificity with regard to the position of the amide bond (i.e. it must be C-terminal), it does not discriminate on the basis of the identity of the terminal residue; in fact, it will cleave off any residue with the exception of arginine (Arg), lysine (Lys) or proline (Pro). However, carboxypeptidase A is most efficient at removing terminal residues with aromatic or bulky aliphatic side-chains (Tyr, Trp, Phe, Leu, Ile).