Formulation: 500 µl Peptide affinity-purified polyclonal antibody
Immunogen: Synthetic peptide from an internal region of human caspase-3
Shelf life (days): 1095
Notes: Apoptosis is associated with many diseases and is induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. Caspase-3 is a key effector caspase in the apoptosis cascade.{7216,6292} The enzyme is efficiently activated by caspase-8, caspase-9, and granzyme B resulting in 17 and 12 kDa active subunits formed from the 34 kDa proenzyme.{7216, 8444} The substrates of caspase-3 are numerous and include pro- and anti-apoptotic proteins, downstream components of the apoptotic machinery (for example, ICAD), as well as structural and homeostatic proteins.{7216,6292} DNA fragmentation and the morphological changes associated with this final stage of apoptosis appears to be dependent upon caspase-3.{6291} Caspase-3 is expressed in a variety of tissues and cells.{8444,8443}
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