Caspase 8 antibody (HL2914)

Caspase 8 antibody (HL2914)
SKU
GTX640257-100
Packaging Unit
100 μl
Manufacturer
GeneTex

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Clone Name: HL2914

Light Chain: Kappa

Application Note: WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 55

Form: Liquid

Buffer (with preservative): PBS, no preservative.

Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)

Background: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]

Uniprot ID: Q14790

Antigen Species: Human

Immunogen: Recombinant fragment of human Caspase 8.

Purification: Affinity purified by Protein A.

Conjugation: Unconjugated

Full Name: caspase 8
More Information
SKU GTX640257-100
Manufacturer GeneTex
Manufacturer SKU GTX640257-100
Package Unit 100 μl
Quantity Unit STK
Reactivity Human
Clonality Monoclonal
Application Western Blotting
Isotype IgG
Human Gene ID 841
Host Rabbit
Conjugate Unconjugated
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