Formulation: A crystalline solid
Formal Name: (9β,13α,14β,20α)-3-hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid, 3-(2-chloro-4-nitro-1H-imidazol-1-yl)propyl ester
Purity: ≥98%
Formula Markup: C35H44ClN3O6
Formula Weight: 638,2
Shelf life (days): 730
CAS Number: 2361009-68-7
Notes: CAY10792 is an anticancer agent.{66238} It binds to heat shock protein 90 (Hsp90) and cell division cycle 37 (Cdc37) in cell-free assays. CAY10792 inhibits the growth of A549, HCT116, U2OS, and MDA-MB-231 cancer cells (IC50s = 0.54, 0.59, 0.57, and 0.57 µM, respectively) but not A549 cells overexpressing Hsp90, Cdc37, or Hsp90 and Cdc37 (IC50s = >100 µM for all). It induces cell cycle arrest at the G0/G1 phase and apoptosis in A549 lung cancer cells when used at a concentration of 0.8 µM. In vivo, CAY10792 (0.5 and 1 mg/kg) reduces tumor weight in an A549 mouse xenograft model.
English
Deutsch
