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Encompassing Amino Acids: 20-91
Application: Useful for SDS-PAGE and avidin-pulldown assays.
Background: CD235a, also known as Glycophorin A (GLPA), is a sialoglycoprotein and a major intrinsic membrane protein on the surface of human erythrocytes. CD235a plays an important role in the prevention of red cell aggregation in the circulatory system. The Glycophorin A gene contains some antigenic alleles of the MNS blood grouping system for which 40 known variants exist. Several of these antigenic variants have implications for pathogen interaction. For example, the Wright b antigen in the helical region of CD235a acts as a receptor for the malaria parasite Plasmodium falciparum. Other variations such as the Mur phenotype causes hemolytic transfusion reaction (HTR) and hemolytic disease in the newborn fetus (HDFN). CD235a is one of the most abundant integral proteins of the red cell membrane, and its genetic sequence varies within a population; therefore, it may also support applications in forensic science.
Description: Recombinant human CD235a, also known as GYPA (Glycophorin A), encompassing amino acids 20-91. This construct contains a C-terminal Avi-Tag™, followed by an His-tag (6xHis). This protein was affinity purified.
Format: Aqueous buffer solution.
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Genbank: NM_002099.7
Host Cell Line: HEK293
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Tags: C-terminal Avi-His-Tag
Uniprot: P02724
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
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