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Applications: Useful for studying protein binding and for screening small molecules and antibodies.
Description: Human CD28 homolog (CD28H), also known as Transmembrane and immunoglobulin domain-containing protein 2 (TMIGD2) and immunoglobulin and prolinerich receptor 1 (IGPR-1). GenBank Accession No. NM_144615, a.a. 23-128 fused at the C-terminus to the Fc portion of human IgG1 followed by a C-terminal AviTag™ expressed in a HEK293 expression system. MW = 40 kDa. This protein is enzymatically biotinylated using Avi-tag™ technology. Biotinylation is confirmed to be greater than 90%. This protein runs at a higher MW by SDS-PAGE due to glycosylation.
Format: Aqueous buffer solution
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Genbank: NM_144615
Storage Stability: At least 6 months at -80°C.
Tags: C-terminal Fc fusion (Human IgG1), C-terminal Avi-tag™
Uniprot: P10747
Warnings: Avoid freeze/thaw cycles. Protein may be diluted to ≥100 µg/ml in PBS + glycerol and stored at -80°C.
Biosafety Level: Not applicable (BSL-1)
References: 1. Zhu, Y., et al., Nat. Commun. 2013; 4:2043.
2. Zhu, Y., et al., J. Immunol. 2015; 194:142.2.