Clone Name: ZR248
Application Note: IHC-P: 1:100-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 64
Positive Control: Hodgkin lymphoma or anaplastic large cell lymphoma
Specificity/Sensitivity: This antibody distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45).
Form: Liquid
Buffer (with preservative): Tissue culture supernatant diluted in Tris-HCl buffer, 0.2% BSA, 0.09% Sodium azide.
Concentration:
Background: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot ID: P28908
Antigen Species: Human
Immunogen: Recombinant human full-length TNFRSF8 protein (CD30)
Purification: unpurified
Conjugation: Unconjugated
Full Name: TNF receptor superfamily member 8
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