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Encompassing Amino Acids: 22-182
Background: CD8 is a co-receptor for the TCR (T cell receptor) in T cells, binding to MHC (major histocompatibility complex) class I proteins. CD8 is a typical marker of cytotoxic T cells and is involved in signaling. CD8 has two isoforms, a and b. CD8b recruits Lck (lymphocyte-specific protein tyrosine kinase) to the TCR-CD3 complex, and Lck phosphorylates multiple proteins involved in activation of cytotoxic T lymphocytes. It is thus critical for the lysis of cancer cells.
Description: Recombinant human CD8a (cluster of differentiation 8 a) transcript 1 encompassing amino acids 22-182. This construct contains a C-terminal Fc domain followed by an Avi-Tag™. The recombinant protein was affinity purified. HiP™ indicates a high purity protein (≥90% pure) with less than 10% aggregation as measured by gel filtration.
Format: Aqueous buffer solution
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Genbank: NM_001768.7
Host Cell Line: HEK293
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Tags: C-terminal FC, C-terminal Avi-Tag™
Uniprot: P01732
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
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