Application Note: WB: 0.1-0.5 μg/mL. IHC-P: 0.5-1 μg/mL. FACS: 1-3 μg/10⁶ cells. ELISA: 0.1-0.5 μg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 21
Form: Liquid
Buffer (with preservative): 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg sodium azide.
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration.)
Background: The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]
Uniprot ID: P60953
Antigen Species: Human
Immunogen: E.coli-derived human CDC42 recombinant protein (Position: K16-C188).
Purification: Purified by antigen-affinity chromatography
Conjugation: Unconjugated
Full Name: cell division cycle 42
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