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Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Description: Cyclin-dependent kinase 7 (CDK7) assembled with Cyclin H and MAT1 comprises an important sub-component of the transcription factor TFIIH. It is known to have dual roles, which include transcription regulation via phosphorylating the C-terminal domain (CTD) of RNA polymerase II as well as controlling cell cycle progression as a CDK activating kinase (CAK). The CDK7 Assay Kit is designed to measure CDK7/Cyclin H/MAT1 activity for screening and profiling applications, using ADP-Glo® as a detection reagent.
Storage Stability: Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival.
Supplied As: The CDK7 Assay Kit comes in a convenient 96-well format, with enough purified recombinant CDK7/Cyclin H/MAT1 enzyme, CDK substrate peptide, ATP and kinase assay buffer for 100 enzyme reactions.
Uniprot: Q24216
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: Uzma A. et al., Nature Review Drug Discovery 14:130-146 (2015)
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