Specificity: Recognizes a neuraminidase-sensitive sialoprotein (CDw75), present on cell membrane and cytoplasm of germinal center B-cells and derived lymphomas. This antibody reacts with RBC precursors of bone marrow, ductal, and ciliated epithelial cells of kidney, breast, prostate, pancreas, lung, and with glioblastomas, astrocytomas, and Reed Sternberg cells in lymphocyte predominant Hodgkin's disease.
Immunogen: Nuclei from pokeweed mitogen-stimulated peripheral blood lymphocytes.