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Encompassing Amino Acids: 430-543
Applications: Useful for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling.
Background: CECR2 is a bromodomain-containing protein that is part of the CERF (CECR2-containing-remodeling factor) complex, which facilitates the perturbation of chromatin structure in an ATP-dependent manner. May be involved through its interaction with RPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis
Description: Human Bromodomain CECR2 (cat eye syndrome chromosome region, candidate 2), GenBank Accession No. NM_031413, a.a. 430-543 corresponding to single bromodomain with N-terminal GST-tag, MW = 40.3 kDa, expressed in an E. coli cell expression system.
Format: Aqueous buffer solution
Formulation: 40 mM Tris-HCl, pH 8, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, and 20% glycerol.
Genbank: NM_031413
Storage Stability: Store at -80°C. Stable for >6 months when stored as directed.
Tags: N-terminal GST-tag
Uniprot: Q9BXF3
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Chen, J., et al., Int J Dev Biol. 2010; 54(5):925-9.
2. Lee SK, et al., Mol Cells. 2012 Jul; 34(1):85-91.