Celastrol, CAS 34157-83-0

Proteasome inhibitor

Product Type: Inhibitor

CAS No.: 34157-83-0

MolecularFormula: C29H38O4

Molecular Weight: 450,6

Source: Synthetic

Purity: >98%

Solubility: Soluble in 45 mg/ml DMSO, 30 mg/ml Ethanol

Appearance: Red Powder

PubChem CID: 122724

Scientific Background: Displays potent antioxidant and anti-inflammatory activity. Inhibits NFB (IC50=270 nM). It induces heat shock response and cytoprotection in various cells. It inhibits 20S proteasome chymotrypsin activity (IC50=2.5 M). Cell permeable.

References: 1. Sethi G., et al. (2007) Blood109: 2727.2. Westerheide S.D., et al. (2004) J. Biol. Chem. 279: 56053.3. Yang H., et al. (2006) Cancer Res. 66: 4758.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• SKU: STRSIH-333-10MG
• Manufacturer: Stressmarq Biosciences
• Manufacturer SKU: SIH-333-10MG
• Package Unit: 10 mg
• Quantity Unit: STK