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Application: Screen and validate antibodies against B7-H4 for drug discovery and research.Screen for compounds or ligands that regulate or inhibit B7-H4 signaling in a cellular context.Optimize and perform biological assays.
Background: B7-H4 is an immune checkpoint that belongs to the B7 family and is encoded by the VTCN1 gene. B7-H4 is expressed on the surface of antigen presenting cells, interacting with currently unidentified ligands to negatively regulate immune cell responses and suppress tumor-associated immunity. B7-H4 also contributes to changes in the tumor microenvironment that benefit cancer cells and support their proliferation, survival, invasion, and metastasis. B7-H4 is highly expressed in some cancer cells, and has been correlated with tumor progression, particularly in ovarian and breast cancer, making it an attractive target for immunotherapy.
Description: B7-H4 CHO Cell line is a recombinant clonal stable CHO-K1 cell line constitutively expressing full length human B7- H4 protein, also known as V-set domain-containing T-cell activation inhibitor 1 (VTCN1); (NM_024626.4). Surface expression of B7-H4 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of B7-H4 expression (Low, Medium and High), to mimic different B7-H4 expression levels in various cancer types.
Host Cell Line: CHO-K1
Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.
Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.
Supplied As: Each vial contains 2 x 106 cells in 1 ml of cell freezing medium (BPS Bioscience #79796)
Uniprot: Q7Z7D3
Warnings: Avoid freeze/thaw cycles
Biosafety Level: BSL-1
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