Products from BPS Bioscience require a minimum order value above 400€
Application: Screen for activators or inhibitors of antibody-mediated signaling for immunotherapy research and drug discovery.
Characterize BAFF-R antibodies and ligands for binding assays.
Background: BAFF Receptor (B-cell activating factor receptor, BAFF-R) is an essential factor for B cell maturation and survival. In humans it is encoded by the TNFRSF13C gene. BAFF-R function is impressively documented in humans by a homozygous deletion, which leads to an almost complete block of B cell development at the stage of immature/transitional B cells. The resulting immunodeficiency is characterized by B-lymphopenia, agammaglobulinemia, and impaired humoral immune responses.
Description: Recombinant human BAFF-R-CHO K1 cell line stably expressing full length human BAFF-R/TNFRSF13C receptor (GenBank Accession: NM_052945.3). Surface expression of BAFF-R was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of BAFF-R expression (High, Medium, Low) to mimic different stages of cancer target cells with various BAFF-R expression levels.
Genbank: NM_052945.3
Host Cell Line: CHO-K1
Mycoplasma Testing: This cell line has been screened using the MycoAlert™ Mycoplasma Detection Kit (Lonza, #LT07-118) to confirm the absence of Mycoplasma contamination. MycoAlert Assay Control Set (Lonza, #LT07-518) was used as a positive control.
Storage Stability: Store in liquid nitrogen immediately upon receipt.
Supplied As: Each vial contains ~ 2 x 10^6 cells in 1 ml of 10% DMSO in FBS.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: BSL-1
English
Deutsch
