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Applications: This cell line is useful for CD70 binding assays, flow cytometry, or for screening for CD70 antibodies. Also useful for immune checkpoint co-stimulatory assay when co-cultured with CD27/NF-κB Reporter-Jurkat cell line (BPS Bioscience #79509).
Background: CD70, also known as TNFSF7, is a cytokine which binds to CD27. CD70 is involved in T-cell activation and induces the proliferation of costimulated T-cells. Moreover, TNFSF7 enhances the generation of cytolytic T-cells. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. Diseases associated with CD70 include acute myocarditis, arthritis, and other inflammatory disorders.
Description: Recombinant CHO-K1 cells constitutively expressing human CD70 (also known as Tumor Necrosis Factor Ligand Superfamily Member 7, TNFSF7, CD27 Ligand, Ki-24 antigen, CD27-L, and CD27LG; GenBank accession #NM_001252).
Host Cell Line: CHO
Mycoplasma Testing: This cell line has been screened using the MycoAlert™ Mycoplasma Detection Kit (Lonza #LT07-118) to confirm the absence of Mycoplasma contamination.
Storage Stability: Store in liquid nitrogen immediately upon receipt
Supplied As: Each vial contains ~2 x 10^6 cells in 1 ml of 10% DMSO
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: BSL-1
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