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Applications: Screen antibodies for immunotherapy researchCharacterize CEACAM6 antibodies and ligandsStudy the biological function of CEACAM6
Background: CEA cell adhesion molecule 6 (CEACAM6, also known as CD66c) is a glycosyl phosphatidyl inositol (GPI)-anchored cell surface glycoprotein that serves as a cell adhesion protein. CEACAM6 is considered a clinical biomarker and candidate therapeutic target in melanoma, lung, colorectal, and pancreatic cancers. It may play a role in tumor progression through regulation of cell migration, invasion, and anoikis, promoting metastasis. It is also known to affect the sensitivity of tumor cells to adenovirus infection, and it serves as a receptor for E. coli adhesion to the surface of intestinal cells in patients with Crohn's disease.
Description: Recombinant CEACAM6 CHO K1 cell line stably expressing the full-length human CEACAM6 receptor (accession number: NM_002483). Surface expression of hCEACAM6 was confirmed by flow cytometry. Each stable clonal cell line was selected for high level of hCEACAM6 expression compared to its parental CHO K1 cells.
Host Cell Line: CHO-K1 cells, Chinese Hamster Ovary, epithelial-like cells, adherent
Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.
Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.
Supplied As: Each vial contains 2 x 106 cells in 1 ml of cell freezing medium (BPS Bioscience, #79796)
Uniprot: P40199
Warnings: Avoid freeze/thaw cycles
Biosafety Level: BSL-1
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