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Applications: Study antibody-mediated signaling for immunotherapy research and drug discoveryScreen and characterize Claudin-4 antibodies and ligands
Background: Claudins are cell-cell adhesion proteins expressed in tight junctions (TJs), the most common apical cell-cell adhesion. Claudin proteins regulate defense and barrier functions, as well as differentiation and polarity in epithelial and endothelial cells. Claudins are regulated through interactions with each other that are coordinated with other transmembrane tight junction proteins and cytosolic scaffold proteins. Of the 14 claudins expressed by the alveolar epithelium, claudin-3, claudin-4, and claudin-18 are the most prominent; each confers unique properties to alveolar barrier function. Aberrant expressions of claudins have been reported in various cancers.Claudin-4 mediates paracellular chloride transport and plays an important renal function through the reabsorption of filtered chloride. The CLDN4 gene is deleted in Williams-Beuren syndrome, leading to multi-systemic neurodevelopmental disorders. The protein acts as a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) during infection by gram-positive Clostridial bacteria, which are responsible for food poisoning and gastrointestinal illnesses. Claudin 4 can be used as a marker for distinguishing malignant mesothelioma from lung cancer and uterine serous carcinoma. As a pancreatic cancer marker, Claudin-4 exhibits superior performance to BerEp4 staining. Claudin-4 may be overexpressed in ovarian cancer, and it accelerates cell migration and invasion in ovarian tumor cell lines.
Description: Recombinant Claudin-4 CHO K1 cell line stably expressing the full-length human Claudin-4 (accession number: NM_001305). Surface expression of hClaudin-4 was confirmed by flow cytometry. Each stable clonal cell line was selected for high level of hClaudin-4 expression compared to the parental CHO K1 cells.
Host Cell Line: CHO-K1 cells, Chinese Hamster Ovary, epithelial-like cells, adherent
Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.
Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.
Supplied As: Each vial contains 2 x 106 cells in 1 ml of cell freezing medium (BPS Bioscience #79796)
Uniprot: O14493
Warnings: Avoid freeze/thaw cycles
Biosafety Level: BSL-1
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