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Applications: Screen and validate antibodies against claudin-9 for drug discovery and research.Screen for compounds that regulate or inhibit claudin-9 signaling in a cellular context.Perform binding assays to screen for potential claudin-9 ligands.
Background: Claudins are integral membrane proteins and major components of tight junction strands that serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Claudin-9 is one of the 27 members of the Claudin family. Diseases associated with Claudin-9 include deafness, autosomal recessive 116, and Hepatitis C viral infection for which it acts as a co-receptor for viral entry
Description: Recombinant clonal CHO cell line stably expressing full-length human claudin-9 (CLDN9 gene accession number NM_020982). Surface expression of claudin-9 was confirmed by flow cytometry. The stable clonal cell line was selected for high levels of claudin-9 expression compared to the parental CHO-K1 cell line.
Host Cell Line: CHO-K1 cells, Chinese Hamster Ovary, epithelial-like cells, adherent
Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species
Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.
Supplied As: Each vial contains 2 x 106 cells in 1 ml of cell freezing medium (BPS Bioscience #79796)
Uniprot: O95484
Warnings: Avoid freeze/thaw cycles
Biosafety Level: BSL-1
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