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Applications: Use as target cells in CAR-T or NK co-culture killing assays.In vitro and in vivo bioluminescence imaging (BLI).
Background: MIA PaCa-2 is a human epithelial cell line derived from the pancreatic cancer tissue of a 65-year-old male. It is commonly used as a tumor model in pancreatic cancer research and therapy development. The genotyping of MIA PaCa-2 confirmed the presence of a homozygous missense mutation (G12C) in KRAS (K-Ras), a homozygous deletion encompassing exons 1, 2 and 3 of the CDKN2A/p16INK4A (cyclin-dependent kinase inhibitor 2A) gene and a homozygous missense mutation (R248W) in exon 7 of TP53 (tumor protein 53, or p53).
Description: Recombinant MIA PaCa-2 cells expressing firefly luciferase and enhanced GFP (eGFP) driven by an EF1a promoter, generated by transduction with Firefly Luciferase-eGFP lentivirus (BPS Bioscience #78741).
Host Cell Line: MIA PaCa-2, human pancreatic carcinoma cell line, adherent.
Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.
Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.
Supplied As: Each vial contains 2 x 106 cells in 1 ml of Cell Freezing Medium (BPS Bioscience #79796)
Warnings: Avoid freeze/thaw cycles
Biosafety Level: BSL-1
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