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Applications: Screen and validate antibodies against EpCAM for drug discovery and researchScreen for compounds that regulate or inhibit EpCAM signaling in a cellular contextPerform binding assays to screen for potential EpCAM ligands
Background: Epithelial cell adhesion molecule (EpCAM, also known as CD90) is a known biomarker of epithelial cells that regulates cell proliferation and differentiation. It is used as an epithelial cell biomarker to detect circulating tumor cells. EpCAM belongs to the small GA733 protein family and is a homophilic transmembrane glycoprotein involved in cell-cell adhesion and tissue plasticity. It is a single-chain membrane-spanning protein with three major domains known as EpEX, involved in epidermal growth factor receptor (EGFR) mediated signaling pathways. Due to the versatile function of EpCAM and its crosstalk with other signaling pathways in cancer, EpCAM is considered an attractive target for cancer diagnosis, prognosis, and potential therapies.
Description: Recombinant clonal CHO cell line stably expressing full-length human EpCAM (NM_002354). Surface expression of EpCAM was confirmed by flow cytometry. The stable clonal cell line was selected for high levels of EpCAM expression compared to the parental CHO-K1 cell line.
Genbank: NM_002354
Host Cell Line: CHO-K1 cells, Chinese Hamster Ovary, epithelial-like cells, adherent
Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.
Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage. Contact technical support at support@bpsbioscience.com if the cells are not frozen in dry ice upon arrival.
Supplied As: Each vial contains >1 x 106 cells in 1 ml of Cell Freezing Medium (BPS Bioscience #79796)
Uniprot: P16422
Warnings: Avoid freeze/thaw cycles
Biosafety Level: BSL-1
References: Liu, Y., et al. Exp Hematol Oncol 11: 97 (2022).
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