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Applications: Use as target cells for anti-FcRL5 CAR T cells, anti-FcRL5 ADC, and bi-specific antibodies.
Background: FcRL5 is a single-pass type 1 membrane protein which contains 8 immunoglobulin-like C2-type domains. FcRL5 may be involved in B cell development and lymphomagenesis. Moreover, it is enriched in malignant plasma cells of patients diagnosed with multiple myeloma, and is an attractive target for antibody-drug conjugates (ADC) and anti-FcRL5 CAR T cells.
Description: Recombinant HEK293 cells constitutively expressing full length human FcRL5 (Fc Receptor Like 5, also known as CD307, ref. seq. NM_031281).
Host Cell Line: HEK293
Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.
Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.
Supplied As: Each vial contains 2 x 106 cells in 1 ml of cell freezing medium (BPS Bioscience, #79796)
Uniprot: Q96RD9
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: BSL-2
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