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Applications: PD-1 binding molecule (such as anti-PD-1 antibody) screening and profiling in a cellular context
Background: The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T cells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. The PD-1 ligands are found on most cancers, and PD-1:PD-L1/2 interaction inhibits T cell activity and allows cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes.
Description: Recombinant HEK293 stably expressing human PD-1 (Programmed Cell Death 1, PDCD1, SLEB2, CD279, GenBank Accession #NM_005018).
Format: Each vial contains 2 x 10^6 cells in 1 ml of 10% DMSO in FBS.
Host Cell Line: HEK293
Mycoplasma Testing: The cell line has been screened using the metabolite-based Mycoplasma Detection Kit (Biotool #B3903) to confirm the absence of Mycoplasma species.
Storage Stability: Immediately upon receipt, store in liquid nitrogen.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: BSL-2
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