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Applications: Screen for activators or inhibitors of PD-1 signaling in a cellular context , screen PD-L1 antibodies for binding affinity Characterize the biological activity of PD-1 interactions with PD-L1
Background: The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated Tcells,to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. The PD-1ligands are found on most cancers, and PD-1:PD-L1/2 interaction inhibits T cell activity andallows cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involvedin regulating autoimmune responses, making these proteins promising therapeutic targets for anumber of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes.
Description: Recombinant CHO-K1 cells constitutively expressing human PD-L1 (Programmed Cell Death 1 Ligand 1, CD274, B7 homolog 1 (B7- H1), GenBank accession # NM_014143) an engineered T cell receptor (TCR) activator.
Format: Aqueous solution containing DMSO
Host Cell Line: CHO
Mycoplasma Testing: The cell line has been screened using the PCR-based Venor™GeM Mycoplasma Detection kit(Sigma-Aldrich) to confirm the absence of Mycoplasma species.
Storage Stability: Immediately upon receipt, store in liquid nitrogen.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: BSL-1
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