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Application: Useful for screening and validating antibodies against PMSA and PMSA CAR-T for immunotherapy research and drug discovery. Also useful for PMSA binding assays to screen for PMSA ligands.
Background: PMSA (prostate-specific membrane antigen), also known as Folate hydrolase 1 (FOLH1), is expressed at high levels on prostate cancer cells. It has been reported to play a role in tumor progression through the PI3K-Akt and MAPK-ERK1/2 pathways. PMSA/FOLH1 has been used as a target for imaging prostate cancer and is expressed in other tumor types and some normal tissues. Currently, PMSA/FOLH1 is the target of clinical trials of CAR-T cells and bi-specific antibodies.
Description: Recombinant clonal stable CHO cell line constitutively expressing full length human PMSA protein (Genbank #NM_004476.1). Surface expression of PMSA was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of PMSA expression to mimic different stages of cancer target cells with various PMSA expression levels.
Host Cell Line: CHO
Mycoplasma Testing: This cell line has been screened using the Quick Test Mycoplasma Detection Kit (Biotool.com, #B39032) to confirm the absence of Mycoplasma contamination.
Storage Stability: Store in liquid nitrogen immediately upon receipt.
Supplied As: Each vial contains ~ 2 x 10^6 cells in 1 ml of FBS + 10% DMSO.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: BSL-1
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