ROR1-CHO Recombinant Cell Line

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Background: Tyrosine-protein kinase transmembrane receptor (ROR1) is an enzyme that in humans is encoded by the ROR1 gene. The ROR1 is expressed by tumor cells of various hematologic and solid malignancies and is largely absent from postnatal healthy cells and tissues. Treatment with a humanized monoclonal antibody specific for ROR1 (UC-961) can inhibit the capacity of ovarian cancer cells to migrate or engraft immune-deficient mice.

Description: Recombinant clonal stable CHO cell line constitutively expressing full length human ROR1 protein (Genbank NM_005012.3). Surface expression of ROR1 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of ROR1 expression (High, Medium, Low) to mimic different stages of cancer target cells with various ROR1 expression levels.

Host Cell Line: CHO

Mycoplasma Testing: This cell line has been screened using the Quick Test Mycoplasma Detection Kit (Biotool.com, #B39032) to confirm the absence of Mycoplasma contamination.

Storage Stability: Store in liquid nitrogen immediately upon receipt.

Supplied As: Each vial contains ~ 2.5 x 10^6 cells in 1 ml of Thaw Medium 3 + 10% DMSO.

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: BSL-1

• SKU: BPS79609-L
• Manufacturer: BPS Bioscience
• Manufacturer SKU: 79609-L
• Package Unit: 2 vials
• Quantity Unit: PAK
• Host: Hamster