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Applications: Characterize antibodies against CD36Screen inhibitors or neutralizing antibodies binding to CD36
Background: CD36 (cluster of differentiation 36) is also known as platelet glycoprotein 4, fatty acid translocase (FAT), scavenger receptor class B member 3 (SCARB3), and glycoprotein 88 (GP88). It is expressed in many cell types including erythrocytes, monocytes, differentiated adipocytes, skeletal muscle cells, mammary and intestinal epithelial cells, and endothelial cells. CD36 is one of the major glycoproteins present at the surface of platelets.CD36 has intricate biological functions, depending on the cell type and ligand. CD36 is a glycoprotein receptor for matrix proteins such collagen, fibronectin, and thrombospondin, acting as an adhesion molecule. Its binding to thrombospondin contributes to vascular biology and angiogenesis, and it also binds lipids such as oxidized phospholipids and low-density lipoprotein, lipoproteins, and long-chain fatty acids. Ligand-induced formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. CD36 regulates cellular fatty acid metabolism in both health and disease by importing its lipid ligands inside cells and by facilitating the cellular uptake of long-chain fatty acids, thereby participating in muscle metabolism, energy storage in adipocytes, and the processing of dietary fat in the intestine.CD36 is involved in various diseases that involve the immune and vascular systems andin diseases for which lipid metabolism is important such as diabetes and obesity, inflammation, atherosclerosis, heart disease, and Alzheimer's disease. In addition, since lipids are an important energy source for tumor cells, CD36 is associated with cancer. Thus, upregulated CD36 expression has been observed in multiple types of cancer and is correlated with poor clinical outcomes. Finally, it plays a role in malaria through its capacity to mediate the adhesion of erythrocytes infected by the parasite responsible for the disease, Plasmodium falciparum.
Description: Recombinant clonal HEK293 cell line stably expressing full length human CD36. The stable clonal cell line was selected for medium and high levels of CD36 expression compared to the parental HEK293 cell line.
Host Cell Line: HEK293
Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.
Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.
Supplied As: Each vial contains 2 x 106 cells in 1 ml of cell freezing medium (BPS Bioscience, #79796)
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: BSL-2
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