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Application: Screen therapeutic antibodies and ADCs (antibody-drug conjugates) targeting CDH6.Co-culture assays to screen CDH6 targeting CAR cells.
Background: Cadherin-6/K-cadherin (CDH6) belongs to the cadherin superfamily of cell adhesion molecules and is a single pass type 1 transmembrane protein. During development, CDH6 plays a role in neural crest morphogenesis and is important for central nervous system and kidney specification. CDH6 is expressed at high levels in tumor cells of diverse origin including, thyroid, gastric, ovarian, and oral squamous cell cancer. CDH6 and other cadherin family members are promising immunotherapy targets for ADC (antibody drug conjugate) and CAR-T therapies due to their role at many stages of cancer progression including tumor initiation, growth, and metastasis.
Description: CDH6 HEK293 Cell Line is a HEK293 stable cell line constitutively expressing human CDH6 (Cadherin-6/K-cadherin) protein (). This cell line was generated by lipid mediated transfection, followed by hygromycin selection, and limiting dilution. Individual clones were screened for CDH6 expression levels by flow cytometry and a high-level CDH6 expression clone was selected to generate this cell line.
Host Cell Line: HEK293, Human Embryonic Kidney, epithelial-like cells, adherent
Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.
Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage. Contact technical support at support@bpsbioscience.com if the cells are not frozen in dry ice upon arrival.
Supplied As: Each vial contains ˃1 x 106 cells in 1 ml of Cell Freezing Medium (BPS Bioscience #79796)
Uniprot: P55285
Warnings: Avoid freeze/thaw cycles
Biosafety Level: BSL-2
References: Bartolomé R., et al., 2021 Molecular Oncology. 15: 1849-1865.
Casal J., et al., 2019 Int. J. Mol. Sci. 20(13), 3373.
Pang L., et al., 2022 J Environ Pathol Toxicol Oncol. 41(1): 55-71.
Punovuori K., et al., 2021 Cell Mol Life Sci. 78(9): 4435-4450.
Suzuki H., et al., 2024 Mol Cancer Ther. 23 (3): 257-271.
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