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Application: Use as an internal control in co-culture killing assaysIn vitro and in vivo bioluminescence imaging
Background: A375 is a melanoma cell line isolated from a patient with malignant melanoma, that is used extensively in toxicology and oncology studies. They are hypotriploid and present an epithelial-like morphology. A375 cells form tumors when injected into immune-compromised mice, with high proliferation rate and invasiveness, and is useful for xenograft studies. It is widely used in mouse models of skin cancer. The presence of the luciferase reporter allows for easy assay readouts as luciferase activity is proportional to the number of cells.
Description: Firefly Luciferase A375 Cell Line is an A375 human melanoma cell line engineered to express Firefly luciferase driven by a CMV promoter. This cell line was generated by transduction with Firefly Luciferase Lentivirus (#79692-P).
Host Cell Line: A375 cells, human melanoma cell line, epithelial cells, adherent.
Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.
Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage. Contact technical support at support@bpsbioscience.com if the cells are not frozen in dry ice upon arrival.
Supplied As: Each vial contains ˃1 x 10 6 cells in 1 ml of Cell Freezing Medium (BPS Bioscience #79796)
Warnings: Avoid freeze/thaw cycles
Biosafety Level: BSL-1
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