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Applications: This cell line is useful for stimulating human GITR on immune cells, as well as binding assays for GITR.
Background: GITRL (CD357; AITRL; TNLG2A), a part of the tumor necrosis factor (ligand) superfamily, member 18 (TNFSF18), is mainly expressed on antigen presenting cells. GITRL engages with the GITR receptor as a co-stimulatory signal to promote lymphocyte activation.
Description: Recombinant CHO-K1 cell constitutively expressing full length human GITRL (NP_005083.2). Surface expression is confirmed by flow cytometry.
Host Cell Line: CHO-K1
Mycoplasma Testing: This cell line has been screened using the MycoAlert™ Mycoplasma Detection Kit (Lonza, Cat. # LT07-118) to confirm the absence of Mycoplasma contamination. MycoAlert Assay Control Set (Lonza, Cat. # LT07-518) was used as a positive control.
Storage Stability: Store in liquid nitrogen immediately upon receipt.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: BSL-1
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